The story is about Homer Alcaraz (Dingdong Dantes) a young businessman who leads a boring life, living a very monotonous life. On the other hand, Proserfina J. Valdez (Marian Rivera) is the exact opposite of Homer. She is a very mysterious woman whom Homer discovers one morning sleeping with him. Proserfina is beautiful, feisty, down-to-earth but mysterious . Her beauty and her unconventional, free-spirited ways immediately attract Homer. Proserfina's presence has changed the young businessman's dull existence. And when Homer decides to share his life with her, Proserfina disappears. Her disappearance is as mysterious as her appearance in Homer's bed.

Thus, Homer has to look for her not only because he loves her but to unravel the mystery of the woman.One day they crossed path but she vanishes as quickly as she entered his life. She was a woman full of mystery which has supposedly syndicate gang roots which Homer needed to uncover.